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$Unique_ID{BRK04012}
$Pretitle{}
$Title{Mucha-Habermann Disease}
$Subject{Mucha-Habermann Disease Pityriasis Lichenoides et Varioliformis Acuta
PLEVA Vasculitis Gianotti-Crosti Syndrome Varicella-Zoster Virus Erythema
Multiforme Pityriasis Rosea }
$Volume{}
$Log{}
Copyright (C) 1990 National Organization for Rare Disorders, Inc.
752:
Mucha-Habermann Disease
** IMPORTANT **
It is possible that the main title of the article (Mucha-Habermann
Disease) is not the name you expected. Please check the SYNONYM listing to
find the alternate names and disorder subdivisions covered by this article.
Synonyms
Pityriasis Lichenoides et Varioliformis Acuta
PLEVA
Information on the following diseases can be found in the Related
Disorders section of this report:
Vasculitis
Gianotti-Crosti Syndrome
Varicella-Zoster Virus
Erythema Multiforme
Pityriasis Rosea
General Discussion
** REMINDER **
The information contained in the Rare Disease Database is provided for
educational purposes only. It should not be used for diagnostic or treatment
purposes. If you wish to obtain more information about this disorder, please
contact your personal physician and/or the agencies listed in the "Resources"
section of this report.
Mucha-Habermann disease is an uncommon skin disorder characterized by
recurrent red, round and elevated lesions (papules), hemorrhages under the
skin (purpura), and blister-like lesions (vesicles). It occurs most often in
young adults and children.
Symptoms
Mucha-Habermann disease is an uncommon skin disorder that usually occurs
during childhood or young adulthood. It is characterized by a recurrent
itchy and burning rash that appears red with round and elevated skin lesions
(papules), hemorrhages under the skin (purpura), and blister like lesions
(vesicles). These lesions usually become scaly, crusted, and can ulcerate
leaving scars. Other symptoms associated with this disease may be headache,
chills, a feeling of ill-health (malaise), and joint pain (arthralgia).
Causes
The exact cause of Mucha-Habermann Disease is not known. Some scientists
believe it may be an autoimmune disorder. Autoimmune disorders are caused
when the body's natural defenses (antibodies, lymphocytes, etc.), against
invading organisms suddenly begin to attack healthy tissue.
Affected Population
Mucha-Habermann Disease is an uncommon skin disorder that affects males and
females in equal numbers. It usually occurs in young adults, but it can
affect children as well.
Related Disorders
Symptoms of the following disorders can be similar to those of Mucha-
Habermann Disease. They may be useful for a differential diagnosis:
Vasculitis is an inflammation of the blood vessel system which includes
the veins, arteries and capillaries. Vasculitis can affect the skin causing
lesions that are flat and red (macules), nodules, or hemorrhages under the
skin (purpura). These lesions can occur on any part of the body. (For more
information on this disorder, choose "Vasculitis" as your search term in the
Rare Disease Database).
Gianotti-Crosti Syndrome is a rare skin disease affecting children
between the ages of nine months to nine years. Major symptoms may include
blisters on the skin of the legs, buttocks or arms. This disorder is usually
preceded by a viral infection. (For more information on this disorder,
choose "Gianotti" as your search term in the Rare Disease Database).
Varicella-zoster infection is a herpes virus that causes chickenpox
during childhood, and shingles (herpes zoster) during adulthood. It is
characterized by a blister-like rash, fever, and sore throat. (For more
information on this disorder, choose "Varicella-Zoster" as your search term
in the Rare Disease Database).
Erythema Multiforme is an inflammatory skin disorder characterized by
symmetric red and blistery (bullous) lesions of the skin or mucous membranes
of the hands, feet and eyelids. (For more information on this disorder,
choose "Erythema Multiforme" as your search term in the Rare Disease
Database.)
Pityriasis Rosea is a self-limited, mild, inflammatory skin eruption
characterized by scaly lesions found most commonly on the trunk. The
disorder is possibly due to an unidentified infectious agent. It may occur
at any age but is seen most frequently in young adults. In temperate
climates, incidence is highest during the spring and autumn.
Therapies: Standard
Treatment of Mucha-Habermann Disease with the antibiotic drug tetracycline,
or corticosteroid or cytotoxic drugs, has provided relief to some people with
this disease. Other treatment is symptomatic and supportive.
Therapies: Investigational
At the present time, a study is being conducted on the effectiveness of the
antibiotic drug Erythromycin, and the use of ultraviolet light as treatments
for Mucha-Habermann Disease. More research must be conducted to determine
the long-term safety and effectiveness of these treatments.
This disease entry is based upon medical information available through
July 1990. Since NORD's resources are limited, it is not possible to keep
every entry in the Rare Disease Database completely current and accurate.
Please check with the agencies listed in the Resources section for the most
current information about this disorder.
Resources
For more information on Mucha-Habermann Disease, please contact:
National Organization for Rare Disorders (NORD)
P.O. Box 8923
New Fairfield, CT 06812-1783
(203) 746-6518
The National Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Information Clearinghouse
Box AMS
Bethesda, MD 20892
(301) 495-4484
References
TEXTBOOK OF MEDICINE, 18th Ed.: James B. Wyngaarden, M.D. et al.; ed.-in-
chief; W.B. Saunders Co., 1988. Pp. 2328.
MUCHA-HABERMANN DISEASE IN CHILDREN -- THE ASSOCIATION WITH RHEUMATIC
DISEASES. J. Ellsworth, et al.; J RHEUMATOL (March - April 1982, issue 9
(2)). Pp. 319-324.
ULTRAVIOLET LIGHT TREATMENT OF A PATIENT WITH PITYRIASIS LICHENOIDES ET
VARIOLIFORMIS ACUTA (MUCHA HABERMAN DISEASE). J. Mackinnon; PHYS THER
(October 1986, issue 66(10)). Pp. 1542-1543.
CLINICAL AND HISTOLOGIC FEATURES IN PITYRIASIS LICHENOIDES ET
VARIOLIFORMIS ACUTA IN CHILDREN. J. Longley, et al.; ARCH DERMATOL (October
1987, issue 123 (10)). Pp. 1335-1339.